Patients receiving which chemotherapy agent should avoid exposure to cold air and cold fluids for several days post-treatment?

Oxaliplatin is an alkylating agent that is commonly used in the treatment of various cancers, particularly colorectal cancer. One of its notable side effects is the development of acute and persistent sensitivity to cold. Patients receiving oxaliplatin often experience symptoms of cold-induced neuropathy, which can manifest as tingling, numbness, or discomfort when exposed to cold air or cold fluids. This sensitivity can occur shortly after administration and may last for several days, prompting healthcare providers to advise patients to avoid any exposure to cold environments, whether it be cold drinks, cold weather, or refrigerator temperatures.

This precaution is particularly important in the days following treatment, as the risk of experiencing these symptoms can be heightened during this period. Managing and mitigating these side effects is crucial for maintaining the patient's comfort and quality of life while undergoing chemotherapy. The other chemotherapy agents listed do not have the same specific and pronounced reaction to cold exposure as oxaliplatin does.