What is the first action to take if a hypersensitivity reaction (HSR) occurs during infusion?

In the case of a hypersensitivity reaction during an infusion, the first and most critical action is to stop the infusion immediately. This step is crucial because continuing the administration of the chemotherapy or immunotherapy agent can exacerbate the reaction and lead to further complications. Stopping the infusion provides the best opportunity to manage the symptoms and prevent potential severe outcomes.

By halting the infusion, healthcare professionals can quickly assess the patient’s condition and initiate appropriate interventions, such as administering antihistamines or other medications as needed. This quick response can be life-saving, especially in cases where the reaction may lead to anaphylaxis or other serious complications. Other actions, like adjusting the infusion rate or notifying the physician after a delay, could delay essential care and worsen the situation. Therefore, stopping the infusion is the most immediate and appropriate response to ensure patient safety.