Which of the following neurotransmitters is primarily associated with CINV?

The primary neurotransmitter associated with chemotherapy-induced nausea and vomiting (CINV) is Substance P. This neuropeptide plays a crucial role in the vomiting reflex and is involved in the transmission of pain and nausea signals in the central nervous system. Substance P works through the neurokinin-1 (NK1) receptor, which has been identified as a key player in mediating the effects of CINV.

Understanding the mechanism of CINV highlights the importance of targeting Substance P in therapeutic interventions. For instance, NK1 receptor antagonists are utilized in clinical practice to effectively manage nausea and vomiting associated with chemotherapy by blocking the action of Substance P, thereby alleviating the symptoms.

Other neurotransmitters like dopamine and serotonin are indeed involved in the vomiting pathway, but they are not the primary mediators of CINV. Dopamine is more associated with the central nervous system's response to distress signals, while serotonin is particularly significant in the acute phase of CINV but does not encompass the full breadth of the mechanisms at play. Norepinephrine is involved in stress responses and can influence gastrointestinal motility, but it is not the key player specifically linked to CINV management. Thus, focusing on Substance P is vital for understanding the underlying mechanisms of CINV