Which side effect is associated with aromatase inhibitors?

Aromatase inhibitors are a class of medications primarily used in the treatment of hormone-receptor-positive breast cancer in postmenopausal women. These drugs work by lowering estrogen levels in the body, which helps slow the growth of hormone-sensitive tumors. One of the notable side effects associated with aromatase inhibitors is weight gain.

The mechanism behind this side effect can be attributed to the changes in hormonal balance and metabolism that occur when estrogen levels are reduced. Reduced estrogen can have various effects on body composition, potentially leading to changes in fat distribution and increased fat mass. This weight gain can also be exacerbated by other factors related to cancer treatment, such as decreased physical activity and changes in diet.

In contrast, increased memory, decreased appetite, and improved sleep are not commonly recognized side effects of aromatase inhibitors. While individuals undergoing cancer treatment may experience a range of symptoms related to their illness and treatment, the specific association of weight gain with aromatase inhibitors is well-documented in clinical literature, making this answer the correct one. Understanding these side effects is crucial for managing patient care and expectations during treatment.